Phospho-TAL1 (S122) Polyclonal Antibody, 100µg, (ATB-P0478)

Description

Background:

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Product datasheet:

Overview
Product Description	Phospho-TAL1 (S122) Polyclonal Antibody, 100µg, (ATB-P0478)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human TAL1 around the phosphorylation site of S122.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription. Yun WJ, et al. Nucleic Acids Res, 2014 Apr. PMID 24470145 Free PMC Article
2. Transcription factor SCL/TAL1 mediates the phosphorylation of MEK/ERK pathway in umbilical cord blood CD34⁺ stem cells during hematopoietic differentiation. Zhou RQ, et al. Blood Cells Mol Dis, 2014 Jun-Aug. PMID 24405580
3. Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL. Zhou Y, et al. Blood, 2013 Dec 19. PMID 24200685
4. Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia. Patel B, et al. Leukemia, 2014 Feb. PMID 23698277
5. Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia. Correia NC, et al. Leukemia, 2013 Jul. PMID 23448994
6. The SCL gene is formed from a transcriptionally complex locus.
   Aplan P.D., Begley C.G., Bertness V., Nussmeier M., Ezquerra A., Coligan J., Kirsch I.R.
   Mol. Cell. Biol. 10:6426-6435(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
7. The DNA sequence and biological annotation of human chromosome 1.
   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
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   Nature 441:315-321(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

8. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
   , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

9. Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.
   Chen Q., Yang C.Y.C., Tsan J.T., Xia Y., Ragab A.H., Peiper S.C., Carroll A., Baer R.
   J. Exp. Med. 172:1403-1408(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-148.
10. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.
    Begley C.G., Aplan P.D., Denning S.M., Haynes B.F., Waldmann T.A., Kirsch I.R.
    Proc. Natl. Acad. Sci. U.S.A. 86:10128-10132(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 118-331. Tissue: Bone marrow.