Phospho-Tensin-2 (Y483) Polyclonal Antibody, 100µg, (ATB-P0268)

Description

Background:

The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.

Product datasheet:

Overview
Product Description	Phospho-Tensin-2 (Y483) Polyclonal Antibody, 100µg, (ATB-P0268)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human Tensin-2 around the phosphorylation site of Y483.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Solution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1. Dai K, et al. PLoS One, 2011. PMID 21765928 Free PMC Article
2. 1H, 15N and 13C chemical shift assignments of the SH2 domain of human tensin2 (TENC1). Chen L, et al. Biomol NMR Assign, 2011 Oct. PMID 21461930
3. Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane. Hafizi S, et al. Biochem Biophys Res Commun, 2010 Aug 27. PMID 20678486
4. Individual domains of Tensin2 exhibit distinct subcellular localisations and migratory effects. Hafizi S, et al. Int J Biochem Cell Biol, 2010 Jan. PMID 19747564
5. Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. Chen L, et al. J Biol Chem, 2012 Jul 27. PMID 22645138 Free PMC Article
6. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
   Hafizi S., Alindri F., Karlsson R., Dahlbaeck B.
   Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), INTERACTION WITH AXL, TISSUE SPECIFICITY. Tissue: Kidney.
7. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.
   Chen H., Duncan I.C., Bozorgchami H., Lo S.H.
   Proc. Natl. Acad. Sci. U.S.A. 99:733-738(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
8. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
   Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
   DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
9. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
   DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] Cited for: SEQUENCE REVISION.
10. The full-ORF clone resource of the German cDNA consortium.
    Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
    BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 759-1409 (ISOFORM 6). Tissue: Colon endothelium and Testis.