Phospho-TIS11B (S92) Polyclonal Antibody, 100µg, (ATB-P0389)

Description

Background:

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Probable regulatory protein involved in regulating the response to growth factors.

Product datasheet:

Overview
Product Description	Phospho-TIS11B (S92) Polyclonal Antibody, 100µg, (ATB-P0389)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human TIS11B around the phosphorylation site of S92.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells. Baou M, et al. Leukemia, 2009 May. PMID 19092855
2. Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36. Ning ZQ, et al. Eur J Immunol, 1996 Oct. PMID 8898945
3. Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes. Barnard RC, et al. Nucleic Acids Res, 1993 Jul 25. PMID 8346037 Free PMC Article
4. Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes. Bustin SA, et al. DNA Cell Biol, 1994 May. PMID 8024689
5. Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control. Viengchareun S, et al. J Am Soc Nephrol, 2014 Oct. PMID 24700863
6. Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes.
   Barnard R.C., Pascall J.C., Brown K.D., McKay I.A., Williams N.S., Bustin S.A.
   Nucleic Acids Res. 21:3580-3580(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
7. Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes.
   Bustin S.A., Nie X.F., Barnard R.C., Kumar V., Pascall J.C., Brown K.D., Leigh I.M., Williams N.S., McKay L.A.
   DNA Cell Biol. 13:449-459(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
8. Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36.
   Ning Z.Q., Norton J.D., Li J., Murphy J.J.
   Eur. J. Immunol. 26:2356-2363(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
9. Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.