Phospho-Trk B (Y706/Y707) Polyclonal Antibody, 100µg, (ATB-P1061)

Description

Background:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Product datasheet:

References:

1. Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington’s disease. Plotkin JL, et al. Neuron, 2014 Jul 2. PMID 24991961
2. Tropomyosin-related receptor kinase B at the invasive front and tumour cell dedifferentiation in gastric cancer. Tanaka K, et al. Br J Cancer, 2014 Jun 10. PMID 24853179
3. Functional DNA methylation in a transcript specific 3’UTR region of TrkB associates with suicide. Maussion G, et al. Epigenetics, 2014 Aug. PMID 24802768
4. Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders. Ray MT, et al. Transl Psychiatry, 2014 May 6. PMID 24802307 Free PMC Article
5. Mood disorders in Huntington’s disease: from behavior to cellular and molecular mechanisms. Pla P, et al. Front Behav Neurosci, 2014. PMID 24795586 Free PMC Article
6. Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2).
   Nakagawara A., Liu X.-G., Ikegaki N., White P.S., Yamashiro D.J., Nycum L.M., Biegel J.A., Brodeur G.M.
   Genomics 25:538-546(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRKB). Tissue: Hippocampus.
7. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.
   Shelton D.L., Sutherland J., Gripp J., Camerato T., Armanini M.P., Phillips H.S., Carroll K., Spencer S.D., Levinson A.D.
   J. Neurosci. 15:477-491(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TRKB AND TRKB-T1). Tissue: Brain.
8. Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.
   Allen S.J., Dawbarn D., Eckford S.D., Wilcock G.K., Ashcroft M., Colebrook S.M., Feeney R., Macgowan S.H.
   Neuroscience 60:825-834(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRKB-T1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Hippocampus.
9. Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism.
   Stoilov P., Castren E., Stamm S.
   Biochem. Biophys. Res. Commun. 290:1054-1065(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TRKB; TRKB-T1; TRKB-T-SHC; 4 AND 5), ALTERNATIVE SPLICING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
10. Full length truncated TrkB sequence identified in a screen for genes regulated by ischemic preconditioning.
    Steinbeck J.A., Thomsen S., Wessig J., Leypoldt F., Lewerenz J., Methner A.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TRKB-T1), VARIANT ARG-309.