Phospho-Trk C (Y516) Polyclonal Antibody, 100µg, (ATB-P0800)

Description

Background:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

Product datasheet:

Overview
Product Description	Phospho-Trk C (Y516) Polyclonal Antibody, 100µg, (ATB-P0800)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Trk C around the phosphorylation site of Y516.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. Luo Y, et al. PLoS Genet, 2013. PMID 23874207 Free PMC Article
2. TrkC promotes survival and growth of leukemia cells through Akt-mTOR-dependent up-regulation of PLK-1 and Twist-1. Kim MS, et al. Mol Cells, 2013 Aug. PMID 23832765 Free PMC Article
3. Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Braskie MN, et al. Neuroimage, 2013 Nov 15. PMID 23727532 Free PMC Article
4. Dependence receptor TrkC is a putative colon cancer tumor suppressor. Genevois AL, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23341610 Free PMC Article
5. Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells. Weinkauf C, et al. Infect Immun, 2011 Oct. PMID 21788388 Free PMC Article
6. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
   McGregor L.M., Baylin S.B., Griffin C.A., Hawkins A.L., Nelkin B.D.
   Genomics 22:267-272(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3). Tissue: Fetal brain.
7. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.
   Shelton D.L., Sutherland J., Gripp J., Camerato T., Armanini M.P., Phillips H.S., Carroll K., Spencer S.D., Levinson A.D.
   J. Neurosci. 15:477-491(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), PARTIAL PROTEIN SEQUENCE. Tissue: Brain.
8. Genomic characterization of the human trkC gene.
   Ichaso N., Rodriguez R.E., Martin-Zanca D., Gonzalez-Sarmiento R.
   Oncogene 17:1871-1875(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
9. Complete sequencing and characterization of 21,243 full-length human cDNAs.
   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.

10. Analysis of the DNA sequence and duplication history of human chromosome 15.
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O’Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O’Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].