Phospho-VDR (S51) Polyclonal Antibody, 100µg, (ATB-P0440)

Description

Background:

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

Product datasheet:

Overview
Product Description	Phospho-VDR (S51) Polyclonal Antibody, 100µg, (ATB-P0440)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human VDR around the phosphorylation site of S51.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Association of FokI and PvuII polymorphisms with breast cancer staging and survival among Caucasian women: a prospective study. Yiallourou AI, et al. J BUON, 2014 Jul-Sep. PMID 25261645
2. The vitamin D receptor: a tumor suppressor in skin. Bikle DD. Adv Exp Med Biol, 2014. PMID 25207372
3. Vitamin D receptor polymorphism FokI and cancer risk: a comprehensive meta-analysis. Gnagnarella P, et al. Carcinogenesis, 2014 Sep. PMID 25053622
4. Vitamin D receptor is highly expressed in precancerous lesions and esophageal adenocarcinoma with significant sex difference. Zhou Z, et al. Hum Pathol, 2014 Aug. PMID 24951052
5. Decreased VDR expression in cutaneous melanomas as marker of tumor progression: new data and analyses. Brożyna AA, et al. Anticancer Res, 2014 Jun. PMID 24922634
6. Cloning and expression of full-length cDNA encoding human vitamin D receptor.
   Baker A.R., McDonnell D.P., Hughes M., Crisp T.M., Mangelsdorf D.J., Haussler M.R., Pike J.W., Shine J., O’Malley B.W.
   Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
7. A single receptor identical with that from intestine/T47D cells mediates the action of 1,25-dihydroxyvitamin D-3 in HL-60 cells.
   Goto H., Chen K.S., Prahl J.M., Deluca H.F.
   Biochim. Biophys. Acta 1132:103-108(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
8. Rae J.L., Shepard A.R.
   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Lens epithelium.
9. Structural organization of the human vitamin D receptor chromosomal gene and its promoter.
   Miyamoto K., Kesterson R.A., Yamamoto H., Taketani Y., Nishiwaki E., Tatsumi S., Inoue Y., Morita K., Takeda E., Pike J.W.
   Mol. Endocrinol. 11:1165-1179(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
10. NIEHS SNPs program
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-230 AND ILE-362.