Phospho-Vinculin (Y821) Polyclonal Antibody, 100µg, (ATB-P1151)

Description

Background:

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Product datasheet:

References:

1. Identification of vinculin as a potential plasma marker for age-related macular degeneration. Kim HJ, et al. Invest Ophthalmol Vis Sci, 2014 Oct 8. PMID 25298412
2. Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. Bays JL, et al. J Cell Biol, 2014 Apr 28. PMID 24751539 Free PMC Article
3. Plasma proteome profiling of atherosclerotic disease manifestations reveals elevated levels of the cytoskeletal protein vinculin. Kristensen LP, et al. J Proteomics, 2014 Apr 14. PMID 24369271
4. Vinculin tension distributions of individual stress fibers within cell-matrix adhesions. Chang CW, et al. J Cell Sci, 2013 Jul 15. PMID 23687380 Free PMC Article
5. Metavinculin: New insights into functional properties of a muscle adhesion protein. Thoss F, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159629
6. Complete sequence of human vinculin and assignment of the gene to chromosome 10.
   Weller P.A., Ogryzko E.P., Corben E.B., Zhidkova N.I., Patel B., Price G.J., Spurr N.K., Koteliansky V.E., Critchley D.R.
   Proc. Natl. Acad. Sci. U.S.A. 87:5667-5671(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Endothelial cell.
7. The full-ORF clone resource of the German cDNA consortium.
   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
   BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Retina.
8. The DNA sequence and comparative analysis of human chromosome 10.
   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
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   Nature 429:375-381(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-234. Tissue: Prostate.
10. Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter.
    Moiseyeva E.P., Weller P.A., Zhidkova N.I., Corben E.B., Patel B., Jasinska I., Koteliansky V.E., Critchley D.R.
    J. Biol. Chem. 268:4318-4325(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56, ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).