Phospho-WWOX (Y33) Polyclonal Antibody, 100µg, (ATB-P0811)

Description

Background:

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.

Product datasheet:

Overview
Product Description	Phospho-WWOX (Y33) Polyclonal Antibody, 100µg, (ATB-P0811)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human WWOX around the phosphorylation site of Y33.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability. Aqeilan RI, et al. Cell Mol Life Sci, 2014 Dec. PMID 25245215
2. Diverse effect of WWOX overexpression in HT29 and SW480 colon cancer cell lines. Nowakowska M, et al. Tumour Biol, 2014 Sep. PMID 24938873 Free PMC Article
3. Methylation status of WWOX gene promoter CpG islands in epithelial ovarian cancer and its clinical significance. Yan H, et al. Biomed Rep, 2013 May. PMID 24648952 Free PMC Article
4. Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people. Yu K, et al. Int J Cancer, 2014 Oct 1. PMID 24585490
5. Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors. Li J, et al. Int J Biol Sci, 2014. PMID 24520212 Free PMC Article
6. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.
   Bednarek A.K., Laflin K.J., Daniel R.L., Liao Q., Hawkins K.A., Aldaz C.M.
   Cancer Res. 60:2140-2145(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35, TISSUE SPECIFICITY. Tissue: Placenta.
7. Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.
   Ried K., Finnis M., Hobson L., Mangelsdorf M., Dayan S., Nancarrow J.K., Woollatt E., Kremmidiotis G., Gardner A., Venter D., Baker E., Richards R.I.
   Hum. Mol. Genet. 9:1651-1663(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 173-414.
8. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth.
   Bednarek A.K., Keck-Waggoner C.L., Daniel R.L., Laflin K.J., Bergsagel P.L., Kiguchi K., Brenner A.J., Aldaz C.M.
   Cancer Res. 61:8068-8073(2001) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), FUNCTION, TISSUE SPECIFICITY.
9. WWOX: a candidate tumor suppressor gene involved in multiple tumor types.
   Paige A.J.W., Taylor K.J., Taylor C., Hillier S.G., Farrington S., Scott D., Porteous D.J., Smyth J.F., Gabra H., Watson J.E.V.
   Proc. Natl. Acad. Sci. U.S.A. 98:11417-11422(2001) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1; 3 AND 7), VARIANTS LEU-98; SER-111; TRP-120; THR-179; PHE-272; ALA-282 AND HIS-314, DISEASE.
10. Cloning of human WOX8 (WWOX v8).
    Chang N.-S.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-179. Tissue: Colon adenocarcinoma.