Acetyl-Histone H2B (K12) Polyclonal Antibody, 100ug, (ATB-K0004)

Description

Background:

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Product datasheet:

Overview
Product Description	Acetyl-Histone H2B (K12) Polyclonal Antibody, 100ug, (ATB-K0004)
Image
Species Reactivities	Human,Mouse,Monkey
Immunogen	Synthesized peptide derived from human Histone H2B around the acetylation site of K12.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Isotype	IGg

References:

1. Antimicrobial polypeptides of the human colonic epithelium. Howell SJ, et al. Peptides, 2003 Nov. PMID 15019208
2. Endotoxin-neutralizing antimicrobial proteins of the human placenta. Kim HS, et al. J Immunol, 2002 Mar 1. PMID 11859126
3. Biochemical and antibacterial analysis of human wound and blister fluid. Frohm M, et al. Eur J Biochem, 1996 Apr 1. PMID 8620898
4. Quantitative proteomic analysis of post-translational modifications of human histones. Beck HC, et al. Mol Cell Proteomics, 2006 Jul. PMID 16627869
5. Antimicrobial peptides in the first line defence of human colon mucosa. Tollin M, et al. Peptides, 2003 Apr. PMID 12860195
6. Genomic structure of putative H2B histone family protein gene.
   Shimizu N., Kudoh J., Shibuya K.
   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
7. The DNA sequence of human chromosome 21.
   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
   , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
   Nature 405:311-319(2000) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

8. Endotoxin-neutralizing antimicrobial proteins of the human placenta.
   Kim H.S., Cho J.H., Park H.W., Yoon H., Kim M.S., Kim S.C.
   J. Immunol. 168:2356-2364(2002) [PubMed] [Europe PMC] Cited for: PROTEIN SEQUENCE OF 2-21, FUNCTION.
9. Biochemical and antibacterial analysis of human wound and blister fluid.
   Frohm M., Gunne H., Bergman A.-C., Agerberth B., Bergman T., Boman A., Liden S., Joernvall H., Boman H.G.
   Eur. J. Biochem. 237:86-92(1996) [PubMed] [Europe PMC] Cited for: PROTEIN SEQUENCE OF 2-13.
10. Antimicrobial peptides in the first line defence of human colon mucosa.
    Tollin M., Bergman P., Svenberg T., Joernvall H., Gudmundsson G.H., Agerberth B.
    Peptides 24:523-530(2003) [PubMed] [Europe PMC] Cited for: PROTEIN SEQUENCE OF 2-13, FUNCTION.