Acetyl-Histone H4 (K5) Polyclonal Antibody, 100ug, (ATB-K0011)

Description

Background:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008]

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Product datasheet:

Overview
Product Description	Acetyl-Histone H4 (K5) Polyclonal Antibody, 100ug, (ATB-K0011)
Image
Species Reactivities	Human,Mouse,Rat,Monkey
Immunogen	Synthesized peptide derived from human Histone H4 around the acetylation site of K5.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Isotype	IGg

References:

1. Acetylation changes at lysine 5 of histone H4 associated with lytic gene promoters during reactivation of Kaposi’s sarcoma-associated herpesvirus. Hwang LR, et al. Acta Virol, 2014. PMID 25283865
2. Global proteome quantification for discovering imatinib-induced perturbation of multiple biological pathways in K562 human chronic myeloid leukemia cells. Xiong L, et al. J Proteome Res, 2010 Nov 5. PMID 20949922 Free PMC Article
3. PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression. Congdon LM, et al. J Cell Biochem, 2010 Jun 1. PMID 20512922
4. Real-time imaging of histone H4 hyperacetylation in living cells. Sasaki K, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805290 Free PMC Article
5. Histone H4 is a major component of the antimicrobial action of human sebocytes. Lee DY, et al. J Invest Dermatol, 2009 Oct. PMID 19536143 Free PMC Article
6. Structure and in vitro transcription of a human H4 histone gene.
   Sierra F., Stein G., Stein J.
   Nucleic Acids Res. 11:7069-7086(1983) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
7. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene.
   Pauli U., Chrysogelos S., Stein G., Stein J., Nick H.
   Science 236:1308-1311(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
8. Isolation and characterization of two human H1 histone genes within clusters of core histone genes.
   Albig W., Kardalinou E., Drabent B., Zimmer A., Doenecke D.
   Genomics 10:940-948(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
9. Association of histone H4 genes with the mammalian testis-specific H1t histone gene.
   Drabent B., Kardalinou E., Bode C., Doenecke D.
   DNA Cell Biol. 14:591-597(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
10. Characterization of the H1.5 gene completes the set of human H1 subtype genes.
    Albig W., Meergans T., Doenecke D.
    Gene 184:141-148(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].