Acetyl-HSP 90 (K435) Polyclonal Antibody, 100ug, (ATB-K0030)

Description

Background:

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Product datasheet:

Overview
Product Description	Acetyl-HSP 90 (K435) Polyclonal Antibody, 100ug, (ATB-K0030)
Image
Species Reactivities	Human, Mouse, Rat
Immunogen	Synthesized peptide derived from the human HSP 90 around the acetylation site of K435.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Isotype	IGg

References:

1. Defect in HSP90 expression in highly differentiated human CD8(+) T lymphocytes. Franzese O, et al. Cell Death Dis, 2014 Jun 12. PMID 24922078
2. Expression of heat shock protein 90 alpha (Hsp90α) in primary neonatal rat myocardial cells exposed to various periods of heat stress in vitro. Islam A, et al. Genet Mol Res, 2014 Apr 14. PMID 24782094
3. Heat shock protein 90 controls HIV-1 reactivation from latency. Anderson I, et al. Proc Natl Acad Sci U S A, 2014 Apr 15. PMID 24706778 Free PMC Article
4. High expression of heat shock protein 90 alpha and its significance in human acute leukemia cells. Tian WL, et al. Gene, 2014 Jun 1. PMID 24680776
5. Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis. Kakeda M, et al. J Am Acad Dermatol, 2014 Apr. PMID 24521827
6. Nucleotide sequence of a full-length cDNA for 90 kDa heat-shock protein from human peripheral blood lymphocytes.
   Soeda E., Yokoyama K., Yamazaki M., Akaogi K., Miwa T., Imai T.
   Nucleic Acids Res. 17:7108-7108(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Peripheral blood lymphocyte.
7. Molecular cloning of cDNA encoding a human heat-shock protein whose expression is induced by adenovirus type 12 E1A in HeLa cells.
   Yamazaki M., Tashiro H., Yokoyama K., Soeda E.
   Agric. Biol. Chem. 54:3163-3170(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
8. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.
   Hickey E., Brandon S.E., Smale G., Lloyd D., Weber L.A.
   Mol. Cell. Biol. 9:2615-2626(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
9. The HSP90 family of genes in the human genome: insights into their divergence and evolution.
   Chen B., Piel W.H., Gui L., Bruford E., Monteiro A.
   Genomics 86:627-637(2005) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), NOMENCLATURE.
10. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].