Phospho-Bcl-2 (T74) Polyclonal Antibody, 100µg, (ATB-P1121)

Description

Background:

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Product datasheet:

References:

1. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Peirs S, et al. Blood, 2014 Dec 11. PMID 25301704
2. Automated quantitative analysis of tissue microarray of 443 patients with colorectal adenocarcinoma: low expression of Bcl-2 predicts poor survival. Nicholson AD, et al. J Am Coll Surg, 2014 Nov. PMID 25127509
3. A newly identified G-quadruplex as a potential target regulating Bcl-2 expression. Sun H, et al. Biochim Biophys Acta, 2014 Oct. PMID 25086254
4. A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum. Akl H, et al. Biochim Biophys Acta, 2014 Oct. PMID 24768714
5. Bcl-2 binds to and inhibits ryanodine receptors. Vervliet T, et al. J Cell Sci, 2014 Jun 15. PMID 24762814
6. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
   Tsujimoto Y., Croce C.M.
   Proc. Natl. Acad. Sci. U.S.A. 83:5214-5218(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
7. Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo.
   Eguchi Y., Ewert D.L., Tsujimoto Y.
   Nucleic Acids Res. 20:4187-4192(1992) [PubMed] [Europe PMC] Cited for: SEQUENCE REVISION TO 96; 110 AND 237.
8. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation.
   Cleary M.L., Smith S.D., Sklar J.
   Cell 47:19-28(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
9. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.
   Seto M., Jaeger U., Hockett R.D., Graninger W., Bennett S., Goldman P., Korsmeyer S.J.
   EMBO J. 7:123-131(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT SER-7.
10. Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene.
    Hua C., Zorn S., Jensen J.P., Coupland R.W., Ko H.S., Wright J.J., Bakhshi A.
    Oncogene Res. 2:263-275(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT SER-7.