Phospho-C/EBP α (T230) Polyclonal Antibody, 100µg, (ATB-P0463)

Description

Background:

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

Product datasheet:

Overview
Product Description	Phospho-C/EBP α (T230) Polyclonal Antibody, 100µg, (ATB-P0463)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human C/EBP α around the phosphorylation site of T230.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells. Guo H, et al. J Leukoc Biol, 2014 Sep. PMID 24868087
2. Dual role of C/EBPα as an activator and repressor of Gαi2 gene transcription. Xu J, et al. Genes Cells, 2013 Dec. PMID 24580717
3. HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling. Zhao T, et al. Retrovirology, 2013 Dec 21. PMID 24359396 Free PMC Article
4. Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency. Toriguchi K, et al. J Gastroenterol Hepatol, 2014 May. PMID 24329600
5. The role of different genetic subtypes of CEBPA mutated AML. Fasan A, et al. Leukemia, 2014 Apr. PMID 24056881
6. Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha).
   Antonson P., Xanthopoulos K.G.
   Biochem. Biophys. Res. Commun. 215:106-113(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Umbilical cord.
7. Transcription factor C/EBP-alpha: novel sites of expression and cloning of the human gene.
   Swart G.W.M., van Groningen J.J.M., van Ruissen F., Bergers M., Schalwijk J.
   Biol. Chem. Hoppe-Seyler 378:373-379(1997)Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
8. SeattleSNPs variation discovery resource
   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-133. Tissue: Pancreas.
10. Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter.
    Choi B.H., Park G.T., Rho H.M.
    J. Biol. Chem. 274:2858-2865(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH HBV PROTEIN X.