Phospho-c-Myc (T58) Polyclonal Antibody, 100µg, (ATB-P0069)

Description

Background:

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5′-CAC[GA]TG-3′. Activates the transcription of growth-related genes.

Product datasheet:

Overview
Product Description	Phospho-c-Myc (T58) Polyclonal Antibody, 100µg, (ATB-P0069)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human c-Myc around the phosphorylation site of T58.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells. Nagesh N, et al. Biochim Biophys Acta, 2015 Jan. PMID 25452213
2. Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations. La Starza R, et al. Blood, 2014 Dec 4. PMID 25270907
3. Diffuse large B-cell lymphomas of immunoblastic type are a major reservoir for MYC-IGH translocations. Horn H, et al. Am J Surg Pathol, 2015 Jan. PMID 25229766
4. Aberrations of MYC are a common event in B-cell prolymphocytic leukemia. Flatley E, et al. Am J Clin Pathol, 2014 Sep. PMID 25125625
5. MYC-associated and double-hit lymphomas: a review of pathobiology, prognosis, and therapeutic approaches. Petrich AM, et al. Cancer, 2014 Dec 15. PMID 25060588
6. The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma.
   Battey J., Moulding C., Taub R., Murphy W., Stewart T., Potter H., Lenoir G., Leder P.
   Cell 34:779-787(1983) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
7. Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.
   Bernard O., Cory S., Gerondakis S., Webb E., Adams J.M.
   EMBO J. 2:2375-2383(1983) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
8. Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29.
   Colby W.W., Chen E.Y., Smith D.H., Levinson A.D.
   Nature 301:722-725(1983) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
9. Nucleotide sequence of cloned cDNA of human c-myc oncogene.
   Watt R., Stanton L.W., Marcu K.B., Gallo R.C., Croce C.M., Rovera G.
   Nature 303:725-728(1983) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
10. Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.
    Rabbitts T.H., Hamlyn P.H., Baer R.
    Nature 306:760-765(1983) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-39.