Phospho-cPLA2 (S505) Polyclonal Antibody, 100 µg, (ATB-P0868)

Description

Background:

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Product datasheet:

References:

1. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP.
   Clark J.D., Lin L.-L., Kriz R.W., Ramesha C.S., Sultzman L.A., Lin A.Y., Milona N., Knopf J.L.
   Cell 65:1043-1051(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT LYS-651.
2. Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2.
   Sharp J., White D., Chiou G., Goodson T., Gamboa G., McClure D., Burgett S., Hoskins J., Skatrud P., Sportsman J., Becker G., Kang L., Roberts E., Kramer R.
   J. Biol. Chem. 266:14850-14853(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-651.
3. NIEHS SNPs program
   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-224 AND LYS-651.
4. The DNA sequence and biological annotation of human chromosome 1.
   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
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   Nature 441:315-321(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-651.
6. cPLA2 is phosphorylated and activated by MAP kinase.
   Lin L.-L., Wartmann M., Lin A.Y., Knopf J.L., Seth A., Davis R.J.
   Cell 72:269-278(1993) [PubMed] [Europe PMC] Cited for: MUTAGENESIS OF SER-505, PHOSPHORYLATION AT SER-505.
7. Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2.
   Sharp J.D., Pickard R.T., Chiou X.G., Manetta J.V., Kovacevic S., Miller J.R., Varshavsky A.D., Roberts E.F., Strifler B.A., Brems D.N., Kramer R.M.
   J. Biol. Chem. 269:23250-23254(1994) [PubMed] [Europe PMC] Cited for: ACTIVE SITE, MUTAGENESIS OF CYS-139; CYS-141; CYS-151; SER-195; SER-215; CYS-220; SER-228; CYS-324; CYS-331; SER-577; CYS-620; CYS-634 AND CYS-726, BIOPHYSICOCHEMICAL PROPERTIES.
8. Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2.
   Huang Z., Payette P., Abdullah K., Cromlish W.A., Kennedy B.P.
   Biochemistry 35:3712-3721(1996) [PubMed] [Europe PMC] Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, ACTIVE SITE, MUTAGENESIS OF SER-228.
9. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine.
   Pickard R.T., Chiou X.G., Strifler B.A., DeFelippis M.R., Hyslop P.A., Tebbe A.L., Yee Y.K., Reynolds L.J., Dennis E.A., Kramer R.M., Sharp J.D.
   J. Biol. Chem. 271:19225-19231(1996) [PubMed] [Europe PMC] Cited for: ACTIVE SITE, CATALYTIC ACTIVITY, MUTAGENESIS OF ARG-200; SER-228 AND ASP-549.
10. Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.
    Boersch-Haubold A.G., Bartoli F., Asselin J., Dudler T., Kramer R.M., Apitz-Castro R., Watson S.P., Gelb M.H.
    J. Biol. Chem. 273:4449-4458(1998) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION AT SER-505 AND SER-727.