Phospho-Cytokeratin 18 (S52) Polyclonal Antibody, 100µg, (ATB-P0547)

Description

Background:

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Product datasheet:

Overview
Product Description	Phospho-Cytokeratin 18 (S52) Polyclonal Antibody, 100µg, (ATB-P0547)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human Cytokeratin 18 around the phosphorylation site of S52.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. The cytokeratin-18 fragment level as a biomarker of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Miyasato M, et al. Clin Chim Acta, 2014 Jun 10. PMID 24667697
2. [Cytokeratin 18 as marker for non-invasive diagnosis and prognosis of acute and chronic liver diseases]. Canbay A, et al. Z Gastroenterol, 2014 Mar. PMID 24622872
3. Increased plasma levels of CK-18 as potential cell death biomarker in patients with HELLP syndrome. John K, et al. Cell Death Dis, 2013 Oct 24. PMID 24157880 Free PMC Article
4. Serum cytochrome c and m30-neoepitope of cytokeratin-18 in chronic hepatitis C. Parfieniuk-Kowerda A, et al. Liver Int, 2014 Apr. PMID 23981197
5. Serum m 30 levels reflects ulcerative colitis activity. Aktaş B, et al. Inflamm Bowel Dis, 2013 Oct. PMID 23945185
6. Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation.
   Oshima R.G., Millan J.L., Cecena G.
   Differentiation 33:61-68(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Placenta.
7. Identification of a cell proliferation-inducing gene.
   Kim J.W.
   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
8. Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
9. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix, Colon, Pancreas, Placenta and Uterus.