Phospho-DOR-1 (S363) Polyclonal Antibody, 100µg, (ATB-P0626)

Description

Background:

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Product datasheet:

Overview
Product Description	Phospho-DOR-1 (S363) Polyclonal Antibody, 100µg, (ATB-P0626)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human DOR-1 around the phosphorylation site of S363.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

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4. Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females. Clarke TK, et al. Pharmacogenomics J, 2014 Jun. PMID 24126707 Free PMC Article
5. Upregulation of the δ opioid receptor in liver cancer promotes liver cancer progression both in vitro and in vivo. Tang B, et al. Int J Oncol, 2013 Oct. PMID 23903826
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    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].