Phospho-Elk-1 (T417) Polyclonal Antibody, 100µg, (ATB-P0097)

Description

Background:

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.

Product datasheet:

References:

1. Human pluripotent stem cells with distinct X inactivation status show molecular and cellular differences controlled by the X-Linked ELK-1 gene. Bruck T, et al. Cell Rep, 2013 Jul 25. PMID 23871667
2. Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features. Laliotis A, et al. Breast, 2013 Feb. PMID 23127278
3. Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma. Morris JF, et al. Hum Pathol, 2013 May. PMID 23114923
4. ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. Odrowaz Z, et al. PLoS Genet, 2012. PMID 22589737 Free PMC Article
5. Effects of resistance exercise intensity on extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase activation in men. Taylor LW, et al. J Strength Cond Res, 2012 Mar. PMID 22343976
6. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.
   Rao V.N., Huebner K., Isobe M., Ar-Rushdi A., Croce C.M., Reddy E.S.P.
   Science 244:66-70(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASN-183.
7. The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus.
   Harindranath N., Mills F.C., Mitchell M.P., Meindl A., Max E.E.
   Gene 221:215-224(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
8. Novel family members HuER71, ELFR, and ELKv among ETS-related genes coexpressed with EWS-FLI1 in Ewing tumor cell lines.
   Aryee D.N.T., Kovar H.
   Submitted (APR-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
9. Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes.
   Yamauchi T., Toko M., Suga M., Hatakeyama T., Isobe M.
   DNA Res. 6:21-27(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). Tissue: Hippocampus.
10. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Urinary bladder.