Phospho-EpoR (Y368) Polyclonal Antibody, 100µg, (ATB-P0552)

Description

Background:

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.

Product datasheet:

Overview
Product Description	Phospho-EpoR (Y368) Polyclonal Antibody, 100µg, (ATB-P0552)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human EpoR around the phosphorylation site of Y368.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Polycythaemia-inducing mutations in the erythropoietin receptor (EPOR): mechanism and function as elucidated by epidermal growth factor receptor-EPOR chimeras. Gross M, et al. Br J Haematol, 2014 May. PMID 24533580
2. Nitric oxide and hypoxia stimulate erythropoietin receptor via MAPK kinase in endothelial cells. Cokic BB, et al. Microvasc Res, 2014 Mar. PMID 24518819 Free PMC Article
3. Erythropoietin receptor expression is a potential prognostic factor in human lung adenocarcinoma. Rózsás A, et al. PLoS One, 2013. PMID 24155958 Free PMC Article
4. Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes. Lisowska KA, et al. PLoS One, 2013. PMID 23577103 Free PMC Article
5. Expression and functional significance of the erythropoietin receptor in hepatocellular carcinoma. Shin M, et al. HPB (Oxford), 2013 Dec. PMID 23496059 Free PMC Article
6. The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p.
   Winkelmann J.C., Penny L.A., Deaven L.L., Forget B.G., Jenkins R.B.
   Blood 76:24-30(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
7. Human erythropoietin receptor: cloning, expression, and biologic characterization.
   Jones S.S., D’Andrea A.D., Haines L.L., Wong G.G.
   Blood 76:31-35(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F). Tissue: Erythroleukemia and Fetal liver.
8. Cloning of the human erythropoietin receptor gene.
   Noguchi C.T., Bae K.S., Chin K., Wada Y., Schechter A.N., Hankins W.D.
   Blood 78:2548-2556(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
9. The erythropoietin receptor gene: cloning and identification of multiple transcripts in an erythroid cell line OCIM1.
   Ehrenman K., St John T.
   Exp. Hematol. 19:973-977(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F). Tissue: Erythroleukemia.
10. A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells.
    Nakamura Y., Komatsu N., Nakauchi H.
    Science 257:1138-1141(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EPOR-F; EPOR-S AND EPOR-T). Tissue: Bone marrow and Megakaryoblast.