Phospho-Flg (Y766) Polyclonal Antibody, 100µg, (ATB-P0650)

Description

Background:

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Product datasheet:

Overview
Product Description	Phospho-Flg (Y766) Polyclonal Antibody, 100µg, (ATB-P0650)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Flg around the phosphorylation site of Y766.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy. Schelch K, et al. Am J Respir Crit Care Med, 2014 Oct 1. PMID 25188816
2. FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer. Seo AN, et al. Virchows Arch, 2014 Nov. PMID 25086725
3. Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer. Cihoric N, et al. Br J Cancer, 2014 Jun 10. PMID 24853178
4. FGFR1 mutations in Rosette-forming glioneuronal tumors of the fourth ventricle. Gessi M, et al. J Neuropathol Exp Neurol, 2014 Jun. PMID 24806303
5. Genetic diagnosis of idiopathic hypogonadotrophic hypogonadism: a new point mutation in the KAL2 gene. Entrala-Bernal C, et al. Hormones (Athens), 2014 Apr-Jun. PMID 24776628
6. The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA.
   Itoh N., Terachi T., Ohta M., Seo M.K.
   Biochem. Biophys. Res. Commun. 169:680-685(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 15). Tissue: Placenta.
7. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.
   Dionne C.A., Crumley G.R., Bellot F., Kaplow J.M., Searfoss G., Ruta M., Burgess W.H., Jaye M., Schlessinger J.
   EMBO J. 9:2685-2692(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH FGF1 AND FGF2. Tissue: Neonatal brain stem.
8. Diverse forms of a receptor for acidic and basic fibroblast growth factors.
   Johnson D.E., Lee P.L., Lu J., Williams L.T.
   Mol. Cell. Biol. 10:4728-4736(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 15; 17 AND 18).
9. Complete sequence of a human receptor for acidic and basic fibroblast growth factors.
   Isacchi A., Bergonzoni L., Sarmientos P.
   Nucleic Acids Res. 18:1906-1906(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Placenta.
10. cDNA cloning and expression of a human FGF receptor which binds acidic and basic FGF.
    Wennstroem S., Sandstroem C., Claesson-Welsh L.
    Growth Factors 4:197-208(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 14), INTERACTION WITH FGF1 AND FGF2. Tissue: Teratocarcinoma.