Phospho-Gab 2 (Y452) Polyclonal Antibody, 100µg, (ATB-P0470)

Description

Background:

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Product datasheet:

Overview
Product Description	Phospho-Gab 2 (Y452) Polyclonal Antibody, 100µg, (ATB-P0470)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Gab 2 around the phosphorylation site of Y452.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Dunn GP, et al. Proc Natl Acad Sci U S A, 2014 Jan 21. PMID 24385586 Free PMC Article
2. Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model. Zhan A, et al. Synapse, 2014 Apr. PMID 24327320
3. GAB2 polymorphism rs2373115 confers susceptibility to sporadic Alzheimer’s disease. Jin C, et al. Neurosci Lett, 2013 Nov 27. PMID 24161894
4. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer’s disease pathology. Zou F, et al. PLoS One, 2013. PMID 23724096 Free PMC Article
5. Gab2 expression in glioma and its implications for tumor invasion. Shi L, et al. Acta Oncol, 2013 Nov. PMID 23231021
6. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
   Nishida K., Yoshida Y., Itoh M., Fukada T., Ohtani T., Shirogane T., Atsumi T., Takahashi-Tezuka M., Ishihara K., Hibi M., Hirano T.
   Blood 93:1809-1816(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PTPN11. Tissue: Myeloma.
7. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
   Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
   DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
8. Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databasesCited for: SEQUENCE REVISION.
9. Human chromosome 11 DNA sequence and analysis including novel gene identification.
   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.
   , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
   Nature 440:497-500(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

10. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
    , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].