Phospho-GATA-4 (S262) Polyclonal Antibody, 100µg, (ATB-P0554)

Description

Background:

This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]

Transcriptional activator that binds to the consensus sequence 5′-AGATAG-3′ and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.

Product datasheet:

Overview
Product Description	Phospho-GATA-4 (S262) Polyclonal Antibody, 100µg, (ATB-P0554)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human GATA-4 around the phosphorylation site of S262.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. [Mutations in the GATA4 gen in patients with non-syndromic congenital heart disease]. Orjuela Quintero DC, et al. Invest Clin, 2014 Sep. PMID 25272520
2. GATA4 immunolocalization in breast carcinoma as a potent prognostic predictor. Takagi K, et al. Cancer Sci, 2014 May. PMID 24862985
3. GATA4 mutations are a cause of neonatal and childhood-onset diabetes. Shaw-Smith C, et al. Diabetes, 2014 Aug. PMID 24696446
4. A novel mutation of GATA4 (K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis. Xiang R, et al. Gene, 2014 Jan 25. PMID 24498650
5. A novel GATA4 loss-of-function mutation responsible for familial dilated cardiomyopathy. Zhao L, et al. Int J Mol Med, 2014 Mar. PMID 24366163
6. Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA.
   Huang W.Y., Cukerman E., Liew C.C.
   Gene 155:219-223(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LEU-39. Tissue: Heart.
7. Palaszewski I., Dame C.
   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
8. DNA sequence and analysis of human chromosome 8.
   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
   , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O’Leary S.B., O’Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
   Nature 439:331-335(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Heart and Lung.
10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].