Phospho-Glycogen Synthase 1 (S645) Polyclonal Antibody, 100µg, (ATB-P0633)

Description

Background:

The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

Product datasheet:

Overview
Product Description	Phospho-Glycogen Synthase 1 (S645) Polyclonal Antibody, 100µg, (ATB-P0633)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Glycogen Synthase 1 around the phosphorylation site of S645.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Regulation of glycogen synthase from mammalian skeletal muscle–a unifying view of allosteric and covalent regulation. Palm DC, et al. FEBS J, 2013 Jan. PMID 23134486
2. Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus. Højlund K, et al. J Clin Endocrinol Metab, 2009 Nov. PMID 19837931
3. Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization. Prats C, et al. J Biol Chem, 2009 Jun 5. PMID 19339242 Free PMC Article
4. Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment. Glintborg D, et al. J Clin Endocrinol Metab, 2008 Sep. PMID 18544618
5. Cardiomyopathy and exercise intolerance in muscle glycogen storage disease 0. Kollberg G, et al. N Engl J Med, 2007 Oct 11. PMID 17928598
6. Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution.
   Browner M.F., Nakano K., Bang A.G., Fletterick R.J.
   Proc. Natl. Acad. Sci. U.S.A. 86:1443-1447(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Muscle.
7. Isolation and characterization of the human muscle glycogen synthase gene.
   Orho M., Nikula-Ijas P., Schalin-Jantti C., Permutt M.A., Groop L.C.
   Diabetes 44:1099-1105(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT NIDDM SER-464.
8. Cloning and characterization of a glycogen synthase cDNA from human endometrium.
   Su X., Schuler L., Shapiro S.S.
   J. Steroid Biochem. Mol. Biol. 59:459-465(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Endometrium.
9. The DNA sequence and biology of human chromosome 19.
   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
   , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
   Nature 428:529-535(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

10. Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
    , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].