Phospho-HSL (S552) Polyclonal Antibody, 100µg, (ATB-P0636)

Description

Background:

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Product datasheet:

Overview
Product Description	Phospho-HSL (S552) Polyclonal Antibody, 100µg, (ATB-P0636)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human HSL around the phosphorylation site of S552.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes. Albert JS, et al. N Engl J Med, 2014 Jun 12. PMID 24848981 Free PMC Article
2. Risk interaction of obesity, insulin resistance and hormone-sensitive lipase promoter polymorphisms (LIPE-60 C > G) in the development of fatty liver. Hsiao PJ, et al. BMC Med Genet, 2013 May 20. PMID 23688034 Free PMC Article
3. Essential role of hormone-sensitive lipase (HSL) in the maintenance of lipid storage in Mycobacterium leprae-infected macrophages. Tanigawa K, et al. Microb Pathog, 2012 May. PMID 22553833
4. Enzyme promiscuity in the hormone-sensitive lipase family of proteins. Giuseppe M, et al. Protein Pept Lett, 2012 Feb. PMID 21933124
5. Genetic variation of hormone sensitive lipase and male infertility. Vatannejad A, et al. Syst Biol Reprod Med, 2011 Dec. PMID 21919688
6. Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium.
   Langin D., Laurell H., Stenson Holst L., Belfrage P., Holm C.
   Proc. Natl. Acad. Sci. U.S.A. 90:4897-4901(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
7. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase.
   Holst L.S., Langin D., Mulder H., Laurell H., Grober J., Bergh A., Mohrenweiser H.W., Edgren G., Holm C.
   Genomics 35:441-447(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
8. SeattleSNPs variation discovery resource
   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-100; HIS-127; SER-146; THR-177; VAL-194; GLN-217; ASN-497; HIS-499 AND SER-938.
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
10. Association and insulin regulated translocation of hormone-sensitive lipase with PTRF.
    Aboulaich N., Oertegren U., Vener A.V., Stralfors P.
    Biochem. Biophys. Res. Commun. 350:657-661(2006) [PubMed] [Europe PMC] Cited for: INTERACTION WITH PTRF, SUBCELLULAR LOCATION.