Phospho-IL-8Rβ (S347) Polyclonal Antibody, 100µg, (ATB-P0936)

Description

Background:

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Product datasheet:

Overview
Product Description	Phospho-IL-8Rβ (S347) Polyclonal Antibody, 100µg, (ATB-P0936)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human IL-8Rβ around the phosphorylation site of S347.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

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2. Volatile anaesthetics reduce neutrophil inflammatory response by interfering with CXC receptor-2 signalling. Müller-Edenborn B, et al. Br J Anaesth, 2015 Jan. PMID 24989774
3. Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits. Auer PL, et al. Nat Genet, 2014 Jun. PMID 24777453 Free PMC Article
4. Blockage of CXCR2 suppresses tumor growth of intrahepatic cholangiocellular carcinoma. Sueoka H, et al. Surgery, 2014 Apr. PMID 24582495
5. High expression of CXCR-2 correlates with lymph node metastasis and predicts unfavorable prognosis in resected esophageal carcinoma. Sui P, et al. Med Oncol, 2014 Feb. PMID 24338377
6. Cloning of complementary DNA encoding a functional human interleukin-8 receptor.
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7. Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.
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8. Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.
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10. SeattleSNPs variation discovery resource
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