Phospho-IL-9R (S519) Polyclonal Antibody, 100µg, (ATB-P0937)

Description

Background:

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

This is a receptor for interleukin-9.

Product datasheet:

Overview
Product Description	Phospho-IL-9R (S519) Polyclonal Antibody, 100µg, (ATB-P0937)
Image
Species Reactivities	Human
Immunogen	Synthesized peptide derived from human IL-9R around the phosphorylation site of S519.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Overexpression of IL-9 receptor in diffuse large B-cell lymphoma. Lv X, et al. Int J Clin Exp Pathol, 2013. PMID 23638223 Free PMC Article
2. A naturally processed HLA-DR-bound peptide from the IL-9 receptor alpha of HTLV-1-transformed T cells serves as a T helper epitope. Kobayashi H, et al. Cancer Immunol Immunother, 2012 Dec. PMID 22638550
3. T(H)2 cytokines modulate the IL-9R expression on human neutrophils. Dragon S, et al. Biochem Biophys Res Commun, 2009 Jun 26. PMID 19401191
4. Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion. Fawaz LM, et al. J Allergy Clin Immunol, 2007 Nov. PMID 17919707
5. Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation. Melén E, et al. J Med Genet, 2004 Dec. PMID 15591265 Free PMC Article
6. Expression cloning of the murine and human interleukin 9 receptor cDNAs.
   Renauld J.-C., Druez C., Kermouni A., Houssiau F., Uyttenhove C., van Roost E., van Snick J.
   Proc. Natl. Acad. Sci. U.S.A. 89:5690-5694(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-331.
7. The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter.
   Kermouni A., van Roost E., Arden K.C., Vermeesch J.R., Weiss S., Godelaine D., Flint J., Lurquin C., Szikora J.-P., Higgs D.R., Marynen P., Renauld J.-C.
   Genomics 29:371-382(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Melanoma.
8. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region.
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   Hum. Mol. Genet. 9:395-401(2000) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

9. SeattleSNPs variation discovery resource
   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-63; GLN-239 AND CYS-288.
10. The DNA sequence of the human X chromosome.
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    Nature 434:325-337(2005) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].