Phospho-IRS-1 (Y896) Polyclonal Antibody, 100µg, (ATB-P0445)

Description

Background:

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Product datasheet:

Overview
Product Description	Phospho-IRS-1 (Y896) Polyclonal Antibody, 100µg, (ATB-P0445)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human IRS-1 around the phosphorylation site of Y896.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. IRS1 G972R missense polymorphism is associated with failure to oral antidiabetes drugs in white patients with type 2 diabetes from Italy. Prudente S, et al. Diabetes, 2014 Sep. PMID 24947357
2. 20-Hydroxyeicosatetraenoic acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at Ser616. Li X, et al. PLoS One, 2014. PMID 24763529 Free PMC Article
3. Association between IRS-1 Gly972Arg polymorphism and colorectal cancer risk. Li P, et al. Tumour Biol, 2014 Jul. PMID 24696264
4. Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer’s disease. Wang W, et al. J Clin Neurosci, 2014 Jul. PMID 24589556
5. Increased interaction with insulin receptor substrate 1, a novel abnormality in insulin resistance and type 2 diabetes. Caruso M, et al. Diabetes, 2014 Jun. PMID 24584551
6. Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
   Araki E., Sun X.J., Haag B.L. III, Chuang L.M., Zhang Y., Yang-Feng T.L., White M.F., Kahn C.R.
   Diabetes 42:1041-1054(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
7. Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma.
   Nishiyama M., Wands J.R.
   Biochem. Biophys. Res. Commun. 183:280-285(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
9. The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro.
   Smith L.K., Bradshaw M., Croall D.E., Garner C.W.
   Biochem. Biophys. Res. Commun. 196:767-772(1993) [PubMed] [Europe PMC] Cited for: TURNOVER.
10. Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.
    Craparo A., O’Neill T.J., Gustafson T.A.
    J. Biol. Chem. 270:15639-15643(1995) [PubMed] [Europe PMC] Cited for: INTERACTION WITH IGF1R.