Phospho-JIP-1 (T103) Polyclonal Antibody, 100µg, (ATB-P0555)

Description

Background:

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Product datasheet:

Overview
Product Description	Phospho-JIP-1 (T103) Polyclonal Antibody, 100µg, (ATB-P0555)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human JIP-1 around the phosphorylation site of T103.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. Beeler N, et al. Brain Res Bull, 2009 Oct 28. PMID 19616077
2. IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation. Tawadros T, et al. Cell Signal, 2005 Aug. PMID 15894166
3. The JNK interacting protein JIP-1 and insulin like growth factor II genes are co-expressed in human embryonic tumours. Engström W, et al. Anticancer Res, 2005 Mar-Apr. PMID 15868948
4. JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). Ikezoe T, et al. Br J Cancer, 2004 May 17. PMID 15138488 Free PMC Article
5. Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1. Allaman-Pillet N, et al. J Biol Chem, 2003 Dec 5. PMID 14507925
6. Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/C-jun-amino-terminal kinase interacting protein-1 (JIP-1) gene.
   Mooser V., Maillard A., Bonny C., Steinmann M., Shaw P., Yarnall D.P., Burns D.K., Schorderet D.F., Nicod P., Waeber G.
   Genomics 55:202-208(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Insulinoma.
7. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
   , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

8. Yu W., Sarginson J., Gibbs R.A.
   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 468-711. Tissue: Brain.
9. Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons.
   Meyer D., Liu A., Margolis B.
   J. Biol. Chem. 274:35113-35118(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH ARHGEF28, SUBCELLULAR LOCATION.
10. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules.
    Verhey K.J., Meyer D., Deehan R., Blenis J., Schnapp B.J., Rapoport T.A., Margolis B.
    J. Cell Biol. 152:959-970(2001) [PubMed] [Europe PMC] Cited for: MUTAGENESIS, INTERACTION WITH KINESIN.