Phospho-Kv1.3 (Y187) Polyclonal Antibody, 100µg, (ATB-P0939)

Description

Background:

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Product datasheet:

Overview
Product Description	Phospho-Kv1.3 (Y187) Polyclonal Antibody, 100µg, (ATB-P0939)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Kv1.3 around the phosphorylation site of Y187.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Physiological role of Kv1.3 channel in T lymphocyte cell investigated quantitatively by kinetic modeling. Hou P, et al. PLoS One, 2014. PMID 24594979 Free PMC Article
2. 1.2 Å X-ray structure of the renal potassium channel Kv1.3 T1 domain. Kremer W, et al. Protein J, 2013 Oct. PMID 24114469
3. Transmembrane segments form tertiary hairpins in the folding vestibule of the ribosome. Tu L, et al. J Mol Biol, 2014 Jan 9. PMID 24055377 Free PMC Article
4. Specific Kv1.3 blockade modulates key cholesterol-metabolism-associated molecules in human macrophages exposed to ox-LDL. Yang Y, et al. J Lipid Res, 2013 Jan. PMID 23099443 Free PMC Article
5. Kv1.3 channels as a potential target for immunomodulation of CD4+ CD28null T cells in patients with acute coronary syndrome. Xu R, et al. Clin Immunol, 2012 Feb. PMID 22169811
6. Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1.
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7. The DNA sequence and biological annotation of human chromosome 1.
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   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases

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9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
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10. Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.
    Philipson L.H., Hice R.E., Schaefer K., Lamendola J., Bell G.I., Nelson D.J., Steiner D.F.
    Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-575. Tissue: Skeletal muscle.