Phospho-MEF-2 (T319) Polyclonal Antibody, 100 µg, (ATB-P0164)

Description

Background:

Transcriptional activator which binds specifically to the MEF2 element, 5′-YTA[AT]₄TAR-3′, found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.

Product datasheet:

References:

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   Pollock R., Treisman R.
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5. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Amygdala.

6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno F.R.
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7. Analysis of the DNA sequence and duplication history of human chromosome 15.
   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O’Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
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   Nature 440:671-675(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 8). Tissue: Pancreas and Uterus.
9. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.
   Yang C.-C., Ornatsky O.I., McDermott J.C., Cruz T.F., Prody C.A.
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    EMBO J. 18:5099-5107(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH HDAC4 AND HDAC9.