Phospho-MEK-2 (T394) Polyclonal Antibody, 100 µg, (ATB-P0169)

Description

Background:

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).

Product datasheet:

References:

1. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.
   Zheng C.-F., Guan K.-L.
   J. Biol. Chem. 268:11435-11439(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle and Skin.
3. Bienvenut W.V., Zebisch A., Kolch W.
   Submitted (DEC-2008) to UniProtKBCited for: PROTEIN SEQUENCE OF 40-51; 53-61; 64-100; 102-112; 164-172; 194-205; 265-297; 362-371 AND 389-397, PHOSPHORYLATION AT THR-394, IDENTIFICATION BY MASS SPECTROMETRY. Tissue: Colon carcinoma.
4. Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.
   Mittal R., Peak-Chew S.Y., McMahon H.T.
   Proc. Natl. Acad. Sci. U.S.A. 103:18574-18579(2006) [PubMed] [Europe PMC] Cited for: PROTEIN SEQUENCE OF 210-231, INACTIVATION BY YERSINIA YOPJ, PHOSPHORYLATION AT SER-222 AND SER-226, ACETYLATION AT SER-222 AND SER-226, IDENTIFICATION BY MASS SPECTROMETRY.
5. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.
   Duesbery N.S., Webb C.P., Leppla S.H., Gordon V.M., Klimpel K.R., Copeland T.D., Ahn N.G., Oskarsson M.K., Fukasawa K., Paull K.D., Vande Woude G.F.
   Science 280:734-737(1998) [PubMed] [Europe PMC] Cited for: CLEAVAGE BY ANTHRAX LETHAL FACTOR.
6. Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.
   Vitale G., Bernardi L., Napolitani G., Mock M., Montecucco C.
   Biochem. J. 352:739-745(2000) [PubMed] [Europe PMC] Cited for: CLEAVAGE BY ANTHRAX LETHAL FACTOR.
7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
   Cell 127:635-648(2006) [PubMed] [Europe PMC] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
8. Phosphoproteome of resting human platelets.
   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
   J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
9. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
   Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
   Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-295, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
10. A quantitative atlas of mitotic phosphorylation.
    Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
    Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND THR-396, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.