Phospho-NFATc4 (S676) Polyclonal Antibody, 100µg, (ATB-P0313)

Description

Background:

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.

Product datasheet:

Overview
Product Description	Phospho-NFATc4 (S676) Polyclonal Antibody, 100µg, (ATB-P0313)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human NFATc4 around the phosphorylation site of S676.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Molecular profiling of acute and chronic rejections of renal allografts. Petra H, et al. Clin Dev Immunol, 2013. PMID 24302958 Free PMC Article
2. Distinct and additive effects of sodium bicarbonate and continuous mild heat stress on fiber type shift via calcineurin/NFAT pathway in human skeletal myoblasts. Yamaguchi T, et al. Am J Physiol Cell Physiol, 2013 Aug 1. PMID 23703530
3. Genetic polymorphisms of the transcription factor NFATc4 and development of new-onset diabetes after transplantation in Hispanic kidney transplant recipients. Chen Y, et al. Transplantation, 2012 Feb 15. PMID 22234350
4. Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination. Fan Y, et al. FEBS Lett, 2008 Dec 10. PMID 19026640
5. Repression of NFAT3 transcriptional activity by estrogen receptors. Qin X, et al. Cell Mol Life Sci, 2008 Sep. PMID 18668201
6. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.
   Hoey T., Sun Y.-L., Williamson K., Xu X.
   Immunity 2:461-472(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANTS ALA-160 AND PRO-800. Tissue: T-cell.
7. Alternative splicing and expression of human and mouse NFAT genes.
   Vihma H., Pruunsild P., Timmusk T.
   Genomics 92:279-291(2008) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23 AND 24), TISSUE SPECIFICITY.
8. Complete sequencing and characterization of 21,243 full-length human cDNAs.
   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 12 AND 16). Tissue: Adrenal gland and Testis.

9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-902 (ISOFORMS 1/2/4/6), VARIANTS ALA-160 AND PRO-800. Tissue: Ovary and Rhabdomyosarcoma.
10. Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.
    Crabtree G.R.
    Cell 96:611-614(1999) [PubMed] [Europe PMC] Cited for: REVIEW.