Phospho-NMDAζ1 (S896) Polyclonal Antibody, 100µg, (ATB-P0696)

Description

Background:

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).

Product datasheet:

Overview
Product Description	Phospho-NMDAζ1 (S896) Polyclonal Antibody, 100µg, (ATB-P0696)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human NMDAζ1 around the phosphorylation site of S896.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Genetic variation of GRIN1 confers vulnerability to methamphetamine-dependent psychosis in a Thai population. Chanasong R, et al. Neurosci Lett, 2013 Sep 13. PMID 23880023
2. Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size. Kalev-Zylinska ML, et al. Stroke, 2013 Aug. PMID 23723305 Free PMC Article
3. Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors. Kaniakova M, et al. J Neurochem, 2012 Nov. PMID 22937865
4. Glutamate input to noradrenergic neurons plays an essential role in the development of morphine dependence and psychomotor sensitization. Parkitna JR, et al. Int J Neuropsychopharmacol, 2012 Nov. PMID 22040728
5. A possible association of responsiveness to adrenocorticotropic hormone with specific GRIN1 haplotypes in infantile spasms. Ding YX, et al. Dev Med Child Neurol, 2010 Nov. PMID 20722663
6. Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing.
   Foldes R.L., Rampersad V., Kamboj R.K.
   Gene 131:293-298(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 11-938 (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 300-938 (ISOFORM 2). Tissue: Brain.
7. Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
   Karp S.J., Masu M., Eki T., Ozawa K., Nakanishi S.
   J. Biol. Chem. 268:3728-3733(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
8. Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
   Planells-Cases R., Sun W., Ferrer-Montiel A.V., Montal M.
   Proc. Natl. Acad. Sci. U.S.A. 90:5057-5061(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
9. Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1).
   Zimmer M., Fink T.M., Franke Y., Lichter P., Spiess J.
   Gene 159:219-223(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
10. Cloning and localization of exon 5-containing isoforms of the NMDAR1 subunit in human and rat brains.
    Nash N.R., Heilman C.J., Rees H.D., Levey A.I.
    J. Neurochem. 69:485-493(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7), VARIANTS MET-540 AND SER-682.