Phospho-Oct-1 (S385) Polyclonal Antibody, 100µg, (ATB-P1021)

Description

Background:

The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

Transcription factor that binds to the octamer motif (5′-ATTTGCAT-3′) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.

Product datasheet:

References:

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2. OCT-1 overexpression is associated with poor prognosis in patients with well-differentiated gastric cancer. Jeong SH, et al. Tumour Biol, 2014 Jun. PMID 24566898
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4. New alternative promoter in regulation of the Oct-1 human gene transcription. Portseva TN, et al. Dokl Biochem Biophys, 2013 Mar-Apr. PMID 23657650
5. Long-term cisplatin exposure promotes methylation of the OCT1 gene in human esophageal cancer cells. Lin R, et al. Dig Dis Sci, 2013 Mar. PMID 23053895
6. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.
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8. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Thymus.

9. The DNA sequence and biological annotation of human chromosome 1.
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   Nature 441:315-321(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

10. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
    , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].