Phospho-Pdcd-4 (S457) Polyclonal Antibody, 100µg, (ATB-P0761)

Description

Background:

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

Product datasheet:

Overview
Product Description	Phospho-Pdcd-4 (S457) Polyclonal Antibody, 100µg, (ATB-P0761)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Pdcd-4 around the phosphorylation site of S457.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4. Fehler O, et al. Nucleic Acids Res, 2014. PMID 25190455 Free PMC Article
2. Expression of Pdcd4 tumor suppressor in human melanoma cells. Vikhreva PN, et al. Anticancer Res, 2014 May. PMID 24778037
3. Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability. Fay MM, et al. J Biol Chem, 2014 Jun 20. PMID 24764298
4. PDCD4 as a predictor of sensitivity to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients. Dou X, et al. Asian Pac J Cancer Prev, 2014. PMID 24568503
5. Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65. Hwang SK, et al. Carcinogenesis, 2014 Jul. PMID 24413684
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7. Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-36.

9. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-36. Tissue: Spleen.
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    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].