Phospho-PLB (S16/T17) Polyclonal Antibody, 100µg, (ATB-P1164)

Description

Background:

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca²⁺. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Product datasheet:

References:

1. Arrhythmogenic right ventricular dysplasia/cardiomyopathy according to revised 2010 task force criteria with inclusion of non-desmosomal phospholamban mutation carriers. Groeneweg JA, et al. Am J Cardiol, 2013 Oct 15. PMID 23871674
2. Structure-function relation of phospholamban: modulation of channel activity as a potential regulator of SERCA activity. Smeazzetto S, et al. PLoS One, 2013. PMID 23308118 Free PMC Article
3. Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy. van der Zwaag PA, et al. Eur J Heart Fail, 2012 Nov. PMID 22820313 Free PMC Article
4. Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy. Ceholski DK, et al. J Biol Chem, 2012 May 11. PMID 22427649 Free PMC Article
5. Probing the helical tilt and dynamic properties of membrane-bound phospholamban in magnetically aligned bicelles using electron paramagnetic resonance spectroscopy. Ghimire H, et al. Biochim Biophys Acta, 2012 Mar. PMID 22172806 Free PMC Article
6. Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6.
   Fujii J., Zarain-Herzberg A., Willard H.F., Tada M., Maclennan D.H.
   J. Biol. Chem. 266:11669-11675(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
7. Cloning of human cardiac phospholamban.
   Salvatore C.A., Jacobson M.A.
   Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA].
8. The human phospholamban gene: structure and expression.
   McTiernan C.F., Frye C.S., Lemster B.H., Kinder E.A., Ogletree-Hughes M.L., Moravec C.S., Feldman A.M.
   J. Mol. Cell. Cardiol. 31:679-692(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
10. Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy.
    Minamisawa S., Sato Y., Tatsuguchi Y., Fujino T., Imamura S., Uetsuka Y., Nakazawa M., Matsuoka R.
    Biochem. Biophys. Res. Commun. 304:1-4(2003) [PubMed] [Europe PMC] Cited for: INVOLVEMENT IN CMH18.