Phospho-Pragmin (Y413) Polyclonal Antibody, 100µg, (ATB-P0236)

Description

Background:

This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]

Product datasheet:

Overview
Product Description	Phospho-Pragmin (Y413) Polyclonal Antibody, 100µg, (ATB-P0236)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Pragmin around the phosphorylation site of Y413.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Safari F, et al. Proc Natl Acad Sci U S A, 2011 Sep 6. PMID 21873224 Free PMC Article
2. Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. Tanaka H, et al. J Biol Chem, 2006 Apr 14. PMID 16481321
3. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
4. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, et al. Science, 2009 Aug 14. PMID 19608861
5. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. Zhang Y, et al. Mol Cell Proteomics, 2005 Sep. PMID 15951569
6. DNA sequence and analysis of human chromosome 8.
   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
   , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O’Leary S.B., O’Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
   Nature 439:331-335(2006) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

7. The nucleotide sequence of a long cDNA clone isolated from human spleen.
   Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-1406, VARIANTS GLN-404; LEU-569; CYS-578 AND THR-1113. Tissue: Spleen.
8. The full-ORF clone resource of the German cDNA consortium.
   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
   BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 820-1406, VARIANT THR-1113. Tissue: Amygdala.
9. The protein kinase complement of the human genome.
   Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S.
   Science 298:1912-1934(2002) [PubMed] [Europe PMC] Cited for: IDENTIFICATION.
10. A quantitative atlas of mitotic phosphorylation.
    Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
    Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696 AND SER-745, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.