Phospho-Rhodopsin (S334) Polyclonal Antibody, 100µg, (ATB-P0966)

Description

Background:

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]

Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.

Product datasheet:

References:

1. Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa. Tam BM, et al. J Neurosci, 2014 Oct 1. PMID 25274813
2. Differential dynamics of extracellular and cytoplasmic domains in denatured States of rhodopsin. Dutta A, et al. Biochemistry, 2014 Nov 25. PMID 25268658
3. Current therapeutic strategies for P23H RHO-linked RP. Nguyen AT, et al. Adv Exp Med Biol, 2014. PMID 24664733
4. A Pro23His mutation alters prenatal rod photoreceptor morphology in a transgenic swine model of retinitis pigmentosa. Scott PA, et al. Invest Ophthalmol Vis Sci, 2014 Apr 28. PMID 24618321 Free PMC Article
5. Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa. McKeone R, et al. Mol Vis, 2014. PMID 24520188 Free PMC Article
6. Isolation and nucleotide sequence of the gene encoding human rhodopsin.
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   Proc. Natl. Acad. Sci. U.S.A. 81:4851-4855(1984) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
7. Genome-wide discovery and analysis of human seven transmembrane helix receptor genes.
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   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
8. The full-ORF clone resource of the German cDNA consortium.
   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
   BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Retina.
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
   The MGC Project Team
   Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
10. Sequence analysis of the 5.34-kb 5′ flanking region of the human rhodopsin-encoding gene.
    Bennett J., Beller B., Sun D., Kariko K.
    Gene 167:317-320(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-120.