Phospho-SH-PTP1 (Y564) Polyclonal Antibody, 100µg, (ATB-P0415)

Description

Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Product datasheet:

Overview
Product Description	Phospho-SH-PTP1 (Y564) Polyclonal Antibody, 100µg, (ATB-P0415)
Image
Species Reactivities	Human,Monkey
Immunogen	Synthesized peptide derived from human SH-PTP1 around the phosphorylation site of Y564.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Methylation and decreased expression of SHP-1 are related to disease progression in chronic myelogenous leukemia. Li Y, et al. Oncol Rep, 2014 May. PMID 24647617
2. PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas. Sooman L, et al. Tumour Biol, 2014 May. PMID 24510345
3. Characterization of SHP-1 protein tyrosine phosphatase transcripts, protein isoforms and phosphatase activity in epithelial cancer cells. Evren S, et al. Genomics, 2013 Nov-Dec. PMID 24100145
4. Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy. Witzig TE, et al. Leukemia, 2014 Jan. PMID 23979523 Free PMC Article
5. SHP1-mediated cell cycle redistribution inhibits radiosensitivity of non-small cell lung cancer. Cao R, et al. Radiat Oncol, 2013 Jul 10. PMID 23842094 Free PMC Article
6. Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
   Yi T., Cleveland J.L., Ihle J.N.
   Mol. Cell. Biol. 12:836-846(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
7. A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.
   Shen S.H., Bastien L., Posner B.I., Chretien P.
   Nature 352:736-739(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Mammary gland.
8. Erratum
   Shen S.H., Bastien L., Posner B.I., Chretien P.
   Nature 353:868-868(1991)Cited for: SEQUENCE REVISION.
9. Isolation of a src homology 2-containing tyrosine phosphatase.
   Plutzky J., Neel B.G., Rosenberg R.D.
   Proc. Natl. Acad. Sci. U.S.A. 89:1123-1127(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
10. Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts.
    Banville D., Stocco R., Shen S.H.
    Genomics 27:165-173(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).