Phospho-Stat3 (Y705) Polyclonal Antibody, 100µg, (ATB-P0251)

Description

Background:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

Product datasheet:

Overview
Product Description	Phospho-Stat3 (Y705) Polyclonal Antibody, 100µg, (ATB-P0251)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Stat3 around the phosphorylation site of Y705.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Hyper-IgE syndrome with a novel STAT3 mutation-a single center study from India. Saikia B, et al. Asian Pac J Allergy Immunol, 2014 Dec. PMID 25543043
2. [Study on impact of ethanol extracts from Sedum sarmentosum in inhibiting STAT-3 signaling and inducing apoptosis of human hepatocellular carcinoma cell line HepG2]. Zeng JY, et al. Zhongguo Zhong Yao Za Zhi, 2014 Sep. PMID 25522626
3. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Yu H, et al. Nat Rev Cancer, 2014 Nov. PMID 25342631
4. STAT3 activation and infiltration of eosinophil granulocytes in mycosis fungoides. Fredholm S, et al. Anticancer Res, 2014 Oct. PMID 25275020
5. Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3. Dasgupta M, et al. J Biol Chem, 2014 Oct 31. PMID 25217633
6. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
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   Cell 77:63-71(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT TYR-561. Tissue: Placenta.
7. Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence.
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   Gene 213:119-124(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
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   Patent number EP2440214, 18-APR-2012Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
9. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

10. SeattleSNPs variation discovery resource
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-143.