Phospho-Syntaxin 1 (S14) Polyclonal Antibody, 100µg, (ATB-P0569)

Description

Background:

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca²⁺-regulation of exocytosis acrosomal reaction in sperm.

Product datasheet:

Overview
Product Description	Phospho-Syntaxin 1 (S14) Polyclonal Antibody, 100µg, (ATB-P0569)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human Syntaxin 1 around the phosphorylation site of S14.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate. Liang B, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218570 Free PMC Article
2. Clinical and molecular characterization of the potential CF disease modifier syntaxin 1A. von Kanel T, et al. Eur J Hum Genet, 2013 Dec. PMID 23572023 Free PMC Article
3. Association analysis of STX1A gene variants in common forms of migraine. Tropeano M, et al. Cephalalgia, 2012 Feb. PMID 22250207
4. α-SNAP prevents docking of the acrosome during sperm exocytosis because it sequesters monomeric syntaxin. Rodríguez F, et al. PLoS One, 2011. PMID 21789195 Free PMC Article
5. Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility. Nakamura K, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2011 Mar 30. PMID 21118708
6. Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis.
   Zhang R.-D., Maksymowych A.B., Simpson L.L.
   Gene 159:293-294(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
7. Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome.
   Osborne L.R., Soder S., Shi X.-M., Pober B., Costa T., Scherer S.W., Tsui L.-C.
   Am. J. Hum. Genet. 61:449-452(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
8. Refinement of the genomic structure of STX1A and mutation analysis in nondeletion Williams syndrome patients.
   Wu Y.-Q., Bejjani B.A., Tsui L.-C., Mandel A., Osborne L.R., Shaffer L.G.
   Am. J. Med. Genet. 109:121-124(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), SEQUENCE REVISION TO 144.
9. Novel isoform of syntaxin 1 is expressed in mammalian cells.
   Jagadish M.N., Tellam J.T., Macaulay S.L., Gough K.H., James D.E., Ward C.W.
   Biochem. J. 321:151-156(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Adipose tissue.
10. Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2.
    Nakayama T., Fujiwara T., Miyazawa A., Asakawa S., Shimizu N., Shimizu Y., Mikoshiba K., Akagawa K.
    Genomics 42:173-176(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).