Phospho-TGFβ RIII (T842) Polyclonal Antibody, 100µg, (ATB-P1161)

Description

Background:

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Product datasheet:

References:

1. Dual role of TGFBR3 in bladder cancer. Liu XL, et al. Oncol Rep, 2013 Sep. PMID 23835618
2. Transient overexpression of TGFBR3 induces apoptosis in human nasopharyngeal carcinoma CNE-2Z cells. Zheng F, et al. Biosci Rep, 2013 Mar 13. PMID 23387308 Free PMC Article
3. Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response. Ganea K, et al. Transl Psychiatry, 2012 Oct 23. PMID 23092981 Free PMC Article
4. Association analysis of TGFBR3 gene with Vogt-Koyanagi-Harada disease and Behcet’s disease in the Chinese Han population. Chen Y, et al. Curr Eye Res, 2012 Apr. PMID 22440163
5. TGFBR3 variation is not a common cause of Marfan-like syndrome and Loeys-Dietz-like syndrome. Singh KK, et al. J Negat Results Biomed, 2012 Feb 2. PMID 22300218 Free PMC Article
6. Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors.
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   Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT PHE-15. Tissue: Placenta.
7. Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene.
   Zippert R., Baessler A., Holmer S.R., Hengstenberg C., Schunkert H.
   J. Hum. Genet. 45:250-253(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-15. Tissue: Blood.
8. NIEHS SNPs program
   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-14; PHE-15; LEU-163; THR-635 AND ARG-765.
9. Complete sequencing and characterization of 21,243 full-length human cDNAs.
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   Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC]

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue.

10. The DNA sequence and biological annotation of human chromosome 1.
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
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    Nature 441:315-321(2006) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].