Phospho-TRβ1 (S142) Polyclonal Antibody, 100µg, (ATB-P0479)

Description

Background:

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Product datasheet:

Overview
Product Description	Phospho-TRβ1 (S142) Polyclonal Antibody, 100µg, (ATB-P0479)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human TRβ1 around the phosphorylation site of S142.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

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4. Down-regulation of thyroid hormone receptor β1 gene expression in gastric cancer involves promoter methylation. Ling Y, et al. Biochem Biophys Res Commun, 2014 Feb 7. PMID 24434154
5. Thyroid hormone resistance: a novel mutation in thyroid hormone receptor beta (THRB) gene – case report. Işık E, et al. Turk J Pediatr, 2013 May-Jun. PMID 24217081
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   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-1). Tissue: Brain.

10. The DNA sequence, annotation and analysis of human chromosome 3.
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
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    Nature 440:1194-1198(2006) [PubMed] [Europe PMC]

    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].