Phospho-TRF1 (S219) Polyclonal Antibody, 100µg, (ATB-P0400)

Description

Background:

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]

Binds the telomeric double-stranded 5′-TTAGGG-3′ repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5′-TTAGGG-3′ repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

Product datasheet:

Overview
Product Description	Phospho-TRF1 (S219) Polyclonal Antibody, 100µg, (ATB-P0400)
Image
Species Reactivities	Human,Mouse
Immunogen	Synthesized peptide derived from human TRF1 around the phosphorylation site of S219.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. A comprehensive model for the recognition of human telomeres by TRF1. Garton M, et al. J Mol Biol, 2013 Aug 23. PMID 23702294 Free PMC Article
2. Telomeric repeat factor 1 protein levels correlates with telomere length in colorectal cancer. Valls-Bautista C, et al. Rev Esp Enferm Dig, 2012 Oct-Nov. PMID 23268632
3. A TRF1-controlled common fragile site containing interstitial telomeric sequences. Bosco N, et al. Chromosoma, 2012 Oct. PMID 22790221 Free PMC Article
4. Conformational fluctuations of a protein-DNA complex and the structure and ordering of water around it. Sinha SK, et al. J Chem Phys, 2011 Dec 28. PMID 22225189
5. The human telomeric protein hTRF1 induces telomere-specific nucleosome mobility. Pisano S, et al. Nucleic Acids Res, 2010 Apr. PMID 20056655 Free PMC Article
6. A human telomeric protein.
   Chong L., van Steensel B., Broccoli D., Erdjument-Bromage H., Hanish J., Tempst P., de Lange T.
   Science 270:1663-1667(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE. Tissue: Cervix carcinoma.
7. de Lange T.
   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databasesCited for: SEQUENCE REVISION TO 14.
8. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.
   Broccoli D., Smogorzewska A., Chong L., de Lange T.
   Nat. Genet. 17:231-235(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-138 (ISOFORM1/2).
9. Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis.
   Shen M., Haggblom C., Vogt M., Hunter T., Lu K.P.
   Proc. Natl. Acad. Sci. U.S.A. 94:13618-13623(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Cervix carcinoma.
10. NIEHS SNPs program
    Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].