Phospho-WAVE1 (Y125) Polyclonal Antibody, 100µg, (ATB-P0680)

Description

Background:

The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

Product datasheet:

Overview
Product Description	Phospho-WAVE1 (Y125) Polyclonal Antibody, 100µg, (ATB-P0680)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human WAVE1 around the phosphorylation site of Y125.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. WAVE1 gene silencing via RNA interference reduces ovarian cancer cell invasion, migration and proliferation. Zhang J, et al. Gynecol Oncol, 2013 Aug. PMID 23680521
2. mRNA encoding WAVE-Arp2/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration. Willett M, et al. Biochem J, 2013 May 15. PMID 23452202
3. High level of WAVE1 expression is associated with tumor aggressiveness and unfavorable prognosis of epithelial ovarian cancer. Zhang J, et al. Gynecol Oncol, 2012 Oct. PMID 22721732
4. [Interaction of WAVE1 and genes involved in multiple drug resistance in children with acute myeloblastic leukemia]. Yang MH, et al. Zhonghua Er Ke Za Zhi, 2010 Mar. PMID 20426950
5. [Expression of WAVE1 in childhood acute lymphocytic leukemia and in the apoptosis of Jurkat cells induced by adriamycin]. Wang Z, et al. Zhongguo Dang Dai Er Ke Za Zhi, 2008 Oct. PMID 18947485
6. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.
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8. The DNA sequence and analysis of human chromosome 6.
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   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

9. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R.
   , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases

   Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    The MGC Project Team
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