Phospho-YB-1 (S102) Polyclonal Antibody, 100µg, (ATB-P0489)

Description

Background:

Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ‘Lys-6’ and ‘Lys-7’. Binds to promoters that contain a Y-box (5′-CTGATTGGCCAA-3′), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5′-[CU]CUGCG-3′ motif in vitro.

Product datasheet:

Overview
Product Description	Phospho-YB-1 (S102) Polyclonal Antibody, 100µg, (ATB-P0489)
Image
Species Reactivities	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human YB-1 around the phosphorylation site of S102.
Properties
Form	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions	-20°C/1 year
Clonality	Polyclonal

References:

1. Association between higher expression of YB-1 and poor prognosis in early-stage extranodal nasal-type natural killer/T-cell lymphoma. Zhao Z, et al. Biomark Med, 2014. PMID 24796623
2. YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin. Khan MI, et al. Oncotarget, 2014 May 15. PMID 24770864 Free PMC Article
3. YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer. Davies AH, et al. Stem Cells, 2014 Jun. PMID 24648416 Free PMC Article
4. High prevalence of Y-box protein-1/p18 fragment in plasma of patients with malignancies of different origin. Tacke F, et al. BMC Cancer, 2014 Jan 20. PMID 24443788 Free PMC Article
5. Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression. Zhang H, et al. Int J Oncol, 2014 Mar. PMID 24378923
6. Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.
   Sakura H., Maekawa T., Imamoto F., Yasuda K., Ishii S.
   Gene 73:499-507(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
7. Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.
   Didier D.K., Schiffenbauer J., Woulfe S.L., Zacheis M., Schwartz B.D.
   Proc. Natl. Acad. Sci. U.S.A. 85:7322-7326(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
8. Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein.
   Kolluri R., Kinniburgh A.J.
   Nucleic Acids Res. 19:4771-4771(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
9. A human protein containing a ‘cold shock’ domain binds specifically to H-DNA upstream from the human gamma-globin genes.
   Horwitz E.M., Maloney K.A., Ley T.J.
   J. Biol. Chem. 269:14130-14139(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Bone marrow.
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal cortex, Eye, Kidney, Muscle, Placenta, Skin, Testis and Uterus.